FacebookTwitterGoogle+RedditEmail

A Decade of Questions Over a Paxil Study Vindicated

In the last few years, highly promoted drugs like Vioxx, Bextra, Baycol, Trovan, Meridia, Seldane, Hismanal, Darvon, Mylotarg, Lotronex, Propulsid, phenylpropanolamine (PPA), phenacetin, Raxar and Redux have been withdrawn for safety risks after millions used them. Sorry about that. Others like Avandia, Cylert, Ketek and Xarelto are under serious safety clouds.

But Big Pharma insists it is unaware of drugs’ true risks until a wide swath of the population uses them and “safety signals” emerge. Facts sometimes suggest otherwise.

In 1977, almost thirty years before Merck admitted its bone drug Fosamax caused jawbone death, its bone scientist observed the action in rats. (The “anti-fracture” drug also causes fractures.)

Years before the label of the antipsychotic Seroquel was changed in 2011 to warn the drug “should be avoided” in combination with at least 12 other medications because of heart risks, at least 99 articles in the U.S. National Library of Medicine linked the drug to “sudden death,”  “QT prolongation” (a heart disturbance that can lead to death), “cardiac arrest” and “death.” In many cases, the Pharma companies “discover” the problems after the drug patent has conveniently expired.

Then there’s Paxil. Paroxetine was a top selling SSRI antidepressant drug for GSK during the “happy pill” craze when Big Pharma was telling everyone they had “depression.” But in 2004, soon after its approval, the New York Attorney General charged that research about the drug published in the Journal of the American Academy of Child and Adolescent Psychiatry (known as “Study 329”) buried the drug’s true risks of suicide in adolescents.

And there were more questions about the research. Former Boston Globe reporter Alison Bass and others reported that the paper was not even written by the 22 doctors and researchers listed as “authors” but by a medical communication company hired by GSK. (Ghostwriting helped make Vioxx, Neurontin, hormone replacement therapy and even the flame retardant chemical deca [Deca-BDE] appear safe, according to published reports.) “You did a superb job with this,” wrote the Paxil paper’s first “author” Martin Keller of Brown University to Sally Laden, a ghostwriter working for Scientific Therapeutics Information. “It is excellent. Enclosed are rather minor changes from me.”

In 2006, “author” Martin Keller, former Professor Emeritus of Psychiatry at Brown, acknowledged that GSK had given him tens of thousands of dollars during and after the time the study was conducted.

There were also questions about where the research appeared. The Journal of the American Academy of Child and Adolescent Psychiatry is a publication of the American Academy of Child and Adolescent Psychiatry which lists the funders of its “treatment guidelines” for children and adolescents with bipolar disorder as Abbott, AstraZeneca, Eli Lilly, Forest, Janssen, Novartis and Pfizer.

Almost fifteen years after the questionable research was published, the furor had not died down. In 2014, two members of the American Academy of Child and Adolescent Psychiatry, Edmund Levin and George Stewart, asked the editor of the Academy’s journal why the discredited paper was still standing and had not been retracted. (A quick look at other scientific papers identified in the press as ghostwritten shows that few are retracted and most are standing, to deceive future generations.)

Then, in September 2015, when many reporters, psychiatrists, researchers and professors had given up the Paxil fight, the British Medical Journal (BMJ) published a reanalysis that amounted to a reversal of the original study. The new research demonstrated that Paxil indeed increases risks of suicide in young people and adolescents.

The reanalysis of Paxil’s suicide risks in the young is a victory for safety activists, medical reporters, the public and freedom of the press. But many pro-pill doctors continue to fight evidence of Paxil’s suicide risks and similar SSRIs. “There is a very reasonable possibility that it has discouraged patients from taking antidepressants and physicians from prescribing these medications [and] the government should rescind the black-box warning on antidepressants altogether,” Richard A. Friedman, a professor of clinical psychiatry at Weill Cornell Medical wrote in the New York Times a month before the Paxil reanalysis.

More articles by:

Martha Rosenberg is an investigative health reporter. She is the author of  Born With A Junk Food Deficiency: How Flaks, Quacks and Hacks Pimp The Public Health (Prometheus).

Weekend Edition
July 20, 2018
Friday - Sunday
Paul Atwood
Peace or Armageddon: Take Your Pick
Paul Street
No Liberal Rallies Yet for the Children of Yemen
Nick Pemberton
The Bipartisan War on Central and South American Women
Jeffrey St. Clair
Roaming Charges: Are You Putin Me On?
Andrew Levine
Sovereignty: What Is It Good For? 
Brian Cloughley
The Trump/NATO Debacle and the Profit Motive
David Rosen
Trump’s Supreme Pick Escalates America’s War on Sex 
Melvin Goodman
Montenegro and the “Manchurian Candidate”
Salvador Rangel
“These Are Not Our Kids”: The Racial Capitalism of Caging Children at the Border
Matthew Stevenson
Going Home Again to Trump’s America
Louis Proyect
Jeremy Corbyn, Bernie Sanders and the Dilemmas of the Left
Patrick Cockburn
Iraqi Protests: “Bad Government, Bad Roads, Bad Weather, Bad People”
Robert Fantina
Has It Really Come to This?
Russell Mokhiber
Kristin Lawless on the Corporate Takeover of the American Kitchen
John W. Whitehead
It’s All Fake: Reality TV That Masquerades as American Politics
Patrick Bobilin
In Your Period Piece, I Would be the Help
Ramzy Baroud
The Massacre of Inn Din: How Rohingya Are Lynched and Held Responsible
Robert Fisk
How Weapons Made in Bosnia Fueled Syria’s Bleak Civil War
Gary Leupp
Trump’s Helsinki Press Conference and Public Disgrace
Josh Hoxie
Our Missing $10 Trillion
Martha Rosenberg
Pharma “Screening” Is a Ploy to Seize More Patients
Basav Sen
Brett Kavanaugh Would be a Disaster for the Climate
David Lau
The Origins of Local AFT 4400: a Profile of Julie Olsen Edwards
Rohullah Naderi
The Elusive Pursuit of Peace by Afghanistan
Binoy Kampmark
Shaking Establishments: The Ocasio-Cortez Effect
John Laforge
18 Protesters Cut Into German Air Base to Protest US Nuclear Weapons Deployment
Christopher Brauchli
Trump and the Swedish Question
Chia-Chia Wang
Local Police Shouldn’t Collaborate With ICE
Paul Lyons
YouTube’s Content ID – A Case Study
Jill Richardson
Soon You Won’t be Able to Use Food Stamps at Farmers’ Markets, But That’s Not the Half of It
Kevin MacKay
Climate Change is Proving Worse Than We Imagined, So Why Aren’t We Confronting its Root Cause?
Thomas Knapp
Elections: More than Half of Americans Believe Fairy Tales are Real
Ralph Nader
Warner Slack—Doctor for the People Forever
Lee Ballinger
Soccer, Baseball and Immigration
Louis Yako
Celebrating the Wounds of Exile with Poetry
Ron Jacobs
Working Class Fiction—Not Just Surplus Value
Perry Hoberman
You Can’t Vote Out Fascism… You Have to Drive It From Power!
Robert Koehler
Guns and Racism, on the Rocks
Nyla Ali Khan
Kashmir: Implementation with Integrity and Will to Resolve
Justin Anderson
Elon Musk vs. the Media
Graham Peebles
A Time of Hope for Ethiopia
Kollibri terre Sonnenblume
Homophobia in the Service of Anti-Trumpism is Still Homophobic (Even When it’s the New York Times)
Martin Billheimer
Childhood, Ferocious Sleep
David Yearsley
The Glories of the Grammophone
Tom Clark
Gameplanning the Patriotic Retributive Attack on Montenegro
FacebookTwitterGoogle+RedditEmail