FacebookTwitterGoogle+RedditEmail

The Return of FrankenSalmon

by MARTHA ROSENBERG

The genetically engineered AquAdvantage salmon, (AAS), often referred to as a “Frankenfish”, is moving through the FDA approval process despite doubts raised at 2010 hearings, in scientific reports and by 400,000 consumers.

The genetically modified salmon, created by Boston-based AquaBounty Technologies, is created to grow twice as fast as wild Atlantic salmon–reaching its full size in 18 months instead of three years. It was created by inserting the coding sequence from a Chinook salmon growth hormone gene under the control of an “antifreeze protein promoter and terminator” from ocean pout into wild Atlantic salmon. No wonder it’s called a Frankenfish.

Ninety-five to 99 percent of AAS are sterile, said AquaBounty at FDA hearings in 2010, so they are unlikely to breed and threaten wild salmon stocks if they escape. (If they did breed, though, it could Jurassic Park-like since AAS eat five times more food than wild salmon and have less fear of predators, according to background materials.) Nor is 1 to 5 percent a small amount considering the 15 million eggs AquaBounty plans to grow: that could amount to 750,000 fertile fish.

To prevent such risks, AquaBounty told an FDA advisory committee it plans to grow the eggs at a facility on Prince Edward Island in Canada, where escapees could not survive. “Water from the facility, including effluent from all floor drains, fish tanks and egg incubators, eventually discharges” into a tidal river that flows into the Gulf of Lawrence, says the AquAdvantage FDA briefing package. Because water temperatures in the winter months are very low and the water has a high salinity, “it is highly unlikely that early life stages of any Atlantic salmon at the facility would be able to survive if they were able to escape.”

But escape into the Gulf of Lawrence is not the only risk. AquaBounty also has safety plans for the adult salmon, which it plans to grow out and slaughter in the country of Panama because that environment  is also hostile to survival. “In the lower reaches of the watershed, the water temperature is in the range of 26 to 28 degrees C, at or near the upper incipient lethal level for Atlantic salmon,” says the FDA report. “As a result, it is extremely unlikely that AquAdvantage Salmon would ever be able to survive and migrate to the Pacific Ocean.”

In the FDA briefing report, AquAdvantage salmon were also found to have high incidences of “jaw erosion” and “focal inflammation” (infection), though the defects are said to be “of low magnitude and not likely to be debilitating to fish in a production setting.” What about the people who eat them? The report also identified low glucose
levels and a possible “increase in the level of IGF-1 [insulin-like growth factor-1] in the AquAdvantage salmon compared to sponsor control fish.”

Perhaps most troubling at the FDA hearings was AquaBounty’s policy for handling dead fish in Panama. In its Environmental Assessment report, it says, “As dead fish are deposited, they will be covered with caustic lime, followed by another layer of dead fish and caustic lime, and so on, until the burial pit is ~0.5 m deep, at which point it will [be] sealed with plastic and covered with soil. Successive pits will be located at a minimum distance of 0.5–1.0 m from those used previously; the aggregate collection of such pits will be located on high ground that is not within the 100-year flood plain. . . . In the event that disposal capacity at the site is inadequate to handle the immediate or aggregate waste volume, alternative means of disposal will be sought.” Why are so many fish expected to die?

More Concerns

There are also questions about the GE fish’s allergic potential. When FDA food scientists Kathleen Jones and Kevin Greenlees presented AquaBounty’s AquAdvantage salmon allergy studies at 2010 hearings, members on the committee considering the approval were appalled at the “science.”

How can safety be determined for levels of allergens when a number that would “unsafe” has not been determined asked members of the Veterinary Medicine Advisory Committee. It’s as if  “you selected a particular allergen in goat meat and another allergen that was in sheep meat and you compared the two and you found a significant difference but both of them were at irrelevantly low numbers,” said Louisiana State University’s David F. Senior, who chaired the committee. “Who cares?”  Other members berated the low numbers of fish used in studies, the inclusion of irrelevant fish in studies which “diluted out the power of the study,” and the generally bad science.

And not only were the studies low powered, some having only six or seven fish in them, there were errors in studies! James D. McKean, with the Department of Veterinary Diagnostic and Production Animal Medicine at Iowa State University, noted there were six “controls” in Table 15 and “in Table 16, there are 7. And I am still unclear as to where that extra sample came from?”

“Nothing reliable can be gained from this study,” said Craig Altier, DVM, from the College of Veterinary Medicine at Cornell University about other data presented, calling the work a “real mess.” This “is an important thing to study and the experiment was a bust, why hasn’t it been done again?”

The briefing packet even says the FDA an not determine if the AquAdvantage salmon would cause more allergies than other fish because excessive culling of “abnormal” salmon and other “technical flaws” in AquaBounty’s study so “skewed” data as to “limit its interpretation that we cannot rely on its results”!  What? Why are so many fish expected to be flawed–and why is approval even considered?

The briefing report also identified low glucose levels in the fish and a possible “increase in the level of IGF-1 [insulin-like growth factor-1] in the AquAdvantage salmon compared to sponsor control fish.”  IGF-1 is linked to cancer and early puberty and its presence in rBGH-created milk was what made the product so controversial. Government scientists have said that IGF-1 is destroyed by digestion or pasteurization, but other scientists disagree.

And there are other concerns besides the AquAdvantage salmon’s allergic potential and levels of its IGF-1. While supporters claim the fast growing fish would supply desirable omega oils,  according to Michael Hansen, PhD, senior scientist with Consumers Union, “in terms of the ratio of omega-3 to omega-6 fatty acids, GE salmon fare worse than wild fish and slightly worse than farmed salmon.”

Finally, there are Jurassic Park-like questions that persist with all genetically modified organisms. The FDA briefing packet discloses an unexpected and unwanted coding “rearrangement” in AquAdvantage salmon in which the original inserted genetic material has moved from “the far upstream promoter regions” to a “downstream location relative to the growth hormone coding region.”  Why.

Despite its documented aberrations, the AquAdvantage salmon will likely not even be  labeled in more evidence that the FDA puts industry before consumers.

Martha Rosenberg’s is an investigative health reporter. She is the author of  Born With A Junk Food Deficiency: How Flaks, Quacks and Hacks Pimp The Public Health (Prometheus).

More articles by:

Martha Rosenberg is an investigative health reporter. She is the author of  Born With A Junk Food Deficiency: How Flaks, Quacks and Hacks Pimp The Public Health (Prometheus).

November 23, 2017
Kenneth Surin
Discussing Trump Abroad
Jay Moore
The Failure of Reconstruction and Its Consequences
Jeffrey St. Clair - Alexander Cockburn
Trout and Ethnic Cleansing
John W. Whitehead
Don’t Just Give Thanks, Pay It Forward One Act of Kindness at a Time
Chris Zinda
Zinke’s Reorganization of the BLM Will Continue Killing Babies
David Krieger
Progress Toward Nuclear Weapons Abolition
Rick Baum
While Public Education is Being Attacked: An American Federation of Teachers Petition Focuses on Maintaining a Minor Tax Break
Paul C. Bermanzohn
The As-If Society
Cole A. Turner
Go Away, Kevin Spacey
Ramzy Baroud
70 Years of Broken Promises: The Untold Story of the Partition Plan
Binoy Kampmark
A New Movement of Rights and the Right in Australia
George Ochenski
Democratic Party: Discouraged, Disgusted, Dysfunctional
Nino Pagliccia
The Governorship Elections in Venezuela: an Interview With Arnold August
Christopher Ketcham
Spanksgiving Day Poem
November 22, 2017
Jonathan Cook
Syria, ‘Experts’ and George Monbiot
William Kaufman
The Great American Sex Panic of 2017
Richard Moser
Young Patriots, Black Panthers and the Rainbow Coalition
Robert Hunziker
Fukushima Darkness
Lee Artz
Cuba Libre, 2017
Mark Weisbrot
Mass Starvation and an Unconstitutional War: US / Saudi Crimes in Yemen
Frank Stricker
Republican Tax Cuts: You’re Right, They’re Not About Economic Growth or Lifting Working-Class Incomes
Edward Hunt
Reconciling With Extremists in Afghanistan
Dave Lindorff
Remembering Media Critic Ed Herman
Nick Pemberton
What to do About Al Franken?
November 21, 2017
Gregory Elich
What is Behind the Military Coup in Zimbabwe?
Louisa Willcox
Rising Grizzly Bear Deaths Raise Red Flag About Delisting
David Macaray
My Encounter With Charles Manson
Patrick Cockburn
The Greatest Threats to the Middle East are Jared Kushner and Mohammed bin Salman
Stephen Corry
OECD Fails to Recognize WWF Conservation Abuses
James Rothenberg
We All Know the Rich Don’t Need Tax Cuts
Elizabeth Keyes
Let There be a Benign Reason For Someone to be Crawling Through My Window at 3AM!
L. Ali Khan
The Merchant of Weapons
Thomas Knapp
How to Stop a Rogue President From Ordering a Nuclear First Strike
Lee Ballinger
Trump v. Marshawn Lynch
Michael Eisenscher
Donald Trump, Congress, and War with North Korea
Tom H. Hastings
Reckless
Franklin Lamb
Will Lebanon’s Economy Be Crippled?
Linn Washington Jr.
Forced Anthem Adherence Antithetical to Justice
Nicolas J S Davies
Why Do Civilians Become Combatants In Wars Against America?
November 20, 2017
T.J. Coles
Doomsday Scenarios: the UK’s Hair-Raising Admissions About the Prospect of Nuclear War and Accident
Peter Linebaugh
On the 800th Anniversary of the Charter of the Forest
Patrick Bond
Zimbabwe Witnessing an Elite Transition as Economic Meltdown Looms
Sheldon Richman
Assertions, Facts and CNN
Ben Debney
Plebiscites: Why Stop at One?
LV Filson
Yemen’s Collective Starvation: Where Money Can’t Buy Food, Water or Medicine
FacebookTwitterGoogle+RedditEmail